![]() Laurus nobilis (bay laurel) is a natural source of biological compounds, and some of its extracts and phytocompounds are also endowed with antiviral activity toward the family of the severe acute respiratory syndrome (SARS)-associated β-coronaviruses. Our findings provide insights into the structure of wild-type and ALS-associated mutants of TDP-43 in a cell. Furthermore, the interaction between ALS-associated TDP-43 and heteronuclear ribonucleoprotein A1 (hnRNP A1) is slightly stronger than that of wild-type TDP-43. In this study, we investigate the possible end-to-end distance between the N- and C-termini of TDP-43, its alterations due to ALS-associated mutations in the IDR, and its apparent molecular shape in live cells using Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS). Its structures have been partially determined, but the whole structure remains elusive. TDP-43 has several domains: an N-terminal domain, two RNA/DNA-recognition motifs, and a C-terminal intrinsically disordered region (IDR). Transactive response element DNA/RNA-binding protein 43 kDa (TDP-43) is the causative protein of amyotrophic lateral sclerosis (ALS) several ALS-associated mutants of TDP-43 have been identified. Companion journals for IJMS include: Biophysica, Obesities, Stresses and Lymphatics.Testimonials: See what our editors and authors say about the IJMS.Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.This journal in the second half of 2022). To publication is undertaken in 2.9 days (median values for papers published in Rapid Publication: manuscripts are peer-reviewed and a firstĭecision is provided to authors approximately 15.9 days after submission acceptance. ![]() Journal Rank: JCR - Q1 ( Biochemistry & Molecular Biology) / CiteScore - Q1 ( Inorganic Chemistry).High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, MEDLINE, Embase, CAPlus / SciFinder, and other databases. ![]()
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